Server crashed again? Inodes mysteriously all used up? Cluster under siege by thousands of high-memory job requests? Chances are there’s a bioinformatician to blame. Bioinformatics research is a necessity when it comes to curing disease, as well as understanding ourselves and the natural world in which we live and, to the dismay of many a sysadmin, it's here to stay. So what can we do about it? In this presentation we will examine the challenges, and explore possible solutions for bioinformatics workflows on traditional HPC systems.